Osimertinib(泰瑞沙)用量是多少
Osimertinib(泰瑞沙)用量是多少,泰瑞沙(Osimertinib)推荐剂量为每日80mg，直至疾病进展或出现无法耐受的毒性。Osimertinib (trade name Tagrisso) is a targeted therapy used in the treatment of non-small cell lung cancer (NSCLC). It belongs to a class of drugs called tyrosine kinase inhibitors (TKIs) and specifically targets tumors with a specific mutation known as EGFR (epidermal growth factor receptor) T790M. Osimertinib has been shown to be highly effective in treating advanced NSCLC with this specific mutation. Now, let's take a closer look at the recommended dosage of Osimertinib.
1. Recommended Dosage of Osimertinib:
The standard recommended dosage of Osimertinib for adult patients with advanced NSCLC is 80 mg once daily. This dosage should be taken orally, with or without food. It is important to follow the prescribed dosage and schedule provided by your healthcare provider.
2. Individualized Dosage Adjustments:
In some cases, healthcare providers may adjust the dosage of Osimertinib based on an individual's response to the treatment or the occurrence of adverse reactions. The dose adjustments may involve either reducing or temporarily interrupting the treatment. It is important to discuss any concerns or side effects with your healthcare provider who can provide appropriate guidance.
3. Renal or Hepatic Impairment:
For patients with mild or moderate renal impairment (creatinine clearance 30-89 mL/min), no dosage adjustment is necessary. However, patients with severe renal impairment or end-stage renal disease (ESRD) should use Osimertinib with caution, as data on its use in this population is limited.
Similarly, for patients with mild or moderate hepatic impairment, no dosage adjustment is required. However, there is limited information available on the use of Osimertinib in patients with severe hepatic impairment, so caution is advised.
4. Missed Dose and Overdose:
If a dose of Osimertinib is missed, it should be taken as soon as you remember. However, if it is already time for the next scheduled dose, the missed dose should be skipped. Double doses should not be taken to make up for a missed dose.
In case of an overdose or accidental ingestion of a higher dose, it is important to seek medical attention immediately. Overdose symptoms may include severe diarrhea, skin rash, or any other severe adverse reactions.
In conclusion, the recommended dosage of Osimertinib for the treatment of advanced NSCLC with EGFR T790M mutation is 80 mg once daily. Dosage adjustments may be made by healthcare providers based on individual response and tolerability. Patients with renal or hepatic impairment should use Osimertinib with caution. If a dose is missed, it should be taken as soon as remembered, but double doses should not be taken. In case of an overdose, immediate medical attention should be sought. Remember to always follow the guidance of your healthcare provider regarding the proper use and dosage of Osimertinib.
