首页 > 用药指导 > 文章详情

Ambisome(安必素)仿制药片

发布时间:2024-02-24 11:36:24 阅读:1006 来源:问药网
分享至

分享到微信朋友圈

×

打开微信,点击底部的“发现”,

使用“扫一扫”即可将网页分享至朋友圈。

安必素

安必素 生产厂家:美国吉利德科学公司(Gilead Sciences) 功能主治:一线抗真菌药物,治疗深部真菌感染有效率高 用法用量:用法用量  静脉用药:开始静脉滴注时先试以1~5mg或按体重一次0.02~0.1mg/kg给药,以后根据患者耐受情况每日或隔日增加5mg,当增至一次 0.6~0.7mg/kg时即可暂停增加剂量,此为一般治疗量。  成人最高一日剂量不超过1mg/kg,每日或隔1~2日给药1次,累积总量 1.5~3.0g,疗程1~3个月,也可长至6个月,视病情及疾病种类而定。  对敏感真菌感染宜采用较小剂量,即成人一次20~30mg,疗程仍宜长。  鞘内给药:首次0.05~0.1mg,以后渐增至每次0.5mg,最大量一次不超过1mg,每周给药2~3次,总量15mg左右。  鞘内给药时宜与小剂量地塞米松或琥珀酸氢化可的松同时给与,并需用脑脊液反复稀释药液,边稀释边缓慢注入以减少不良反应。  局部用药:气溶吸入时成人每次5~10mg,用灭菌注射用水溶解成0.2%~0.3%溶液应用;超声雾化吸入时本品浓度为0.01%~0.02%,每日吸入2~3次,每次吸入5~10ml;持续膀胱冲洗时每日以两性霉素B 5mg加入1000ml灭菌注射用水中,按每小时注入40ml速度进行冲洗,共用5~10日。  静脉滴注或鞘内给药时,均先以灭菌注射用水10ml配制本品50mg,或5ml配制25mg,然后用5%葡萄糖注射液稀释(不可用氯化钠注射液,因可产生沉淀),滴注液的药物浓度不超过10mg/100ml,避光缓慢静滴,每次滴注时间需6小时以上,稀释用葡萄糖注射液的pH值应在4.2以上。  鞘内注射时可取5mg/ml浓度的药液1ml,加5%葡萄糖注射液19ml稀释,使最终浓度成250μg/ml。  注射时取所需药液量以脑脊液5~30ml反复稀释,并缓慢注入。  鞘内注射液的药物浓度不可高于25mg/100ml,pH值应在4.2以上。
查看详情

Ambisome(安必素)仿制药片,Ambisome(AmBisome)的版本有:1、美国吉利德版本;2、美国迈兰版本。代购价格是1600元左右,不同版本价格不同,以实际为准。请选择正规海外代购渠道,以保证产品质量。

Ambisome (安必素) is a generic medication used to treat fungal infections. In this article, we will explore the details of Ambisome, its uses, and its effectiveness in fighting fungal infections.

1. What is Ambisome?

Ambisome is an antifungal medication that belongs to the class of drugs known as liposomal formulations. It contains the active ingredient amphotericin B, which is highly effective against a broad spectrum of fungal infections. Ambisome is commonly used to treat invasive aspergillosis, cryptococcal meningitis, and other systemic fungal infections that are resistant to other antifungal medications.

2. How does Ambisome work?

Ambisome works by binding to the fungal cell membranes, causing them to become porous and leaky. This disrupts the structure and function of the fungal cells, leading to their death. The liposomal formulation of Ambisome helps to deliver the medication more effectively to the site of infection and reduces the risk of toxicity to the body's cells.

3. Advantages of Ambisome

One of the main advantages of Ambisome is its enhanced efficacy against difficult-to-treat fungal infections. It has been particularly effective in treating invasive fungal infections in immunocompromised patients, such as those with HIV/AIDS or undergoing organ transplantation. Ambisome has also shown good results in cases where other antifungal medications have failed.

Moreover, Ambisome has a lower incidence of side effects compared to conventional amphotericin B formulations. This is because the liposomal structure of Ambisome allows for slower and more controlled release of the drug, reducing its toxicity to healthy cells.

4. Administration and Precautions

Ambisome is administered intravenously and requires close monitoring in a hospital or clinical setting. The dosage and duration of treatment depend on the type and severity of the fungal infection, as well as the patient's overall health condition. Careful monitoring of kidney function and electrolyte levels is essential during treatment with Ambisome.

While Ambisome is generally considered safe, some precautions need to be taken. Patients with a history of allergic reactions to amphotericin B or any of the components of Ambisome should avoid this medication. It should also be used with caution in patients with pre-existing kidney or liver dysfunction.

In conclusion, Ambisome is a potent antifungal medication used to treat various types of fungal infections. Its liposomal formulation enhances its efficacy and reduces the risk of side effects. However, as with any medication, it is important to follow the prescribed dosage and discuss any concerns or potential interactions with a healthcare professional.