Baricitinib(巴瑞替尼)艾乐明有哪些禁忌
Baricitinib(巴瑞替尼)艾乐明有哪些禁忌,艾乐明(Baricitinib)禁忌为：1、对巴瑞替尼或药物中的任何成分过敏的患者禁用；2、存在严重活动性感染的患者禁用；3、具有严重肝功能损害的患者禁用；4、孕妇患者禁用；5、哺乳期妇女患者禁用。Baricitinib (巴瑞替尼) is a medication used for the treatment of rheumatoid arthritis, COVID-19, and alopecia areata. However, like any medication, there are certain contraindications and precautions that need to be considered before using it. In this article, we will explore the contraindications associated with Baricitinib and provide accurate information regarding its use.
1. Contraindications of Baricitinib:
Baricitinib is contraindicated in certain situations where its use could potentially be harmful to the patient. These contraindications include:
1.1. Hypersensitivity:
Baricitinib should not be used in individuals who have a known hypersensitivity or allergic reaction to Baricitinib or any of its components. Hypersensitivity reactions can range from mild skin rashes to severe allergic reactions, including anaphylaxis, which can be life-threatening.
1.2. Active Infections:
The use of Baricitinib is contraindicated in patients with active infections, such as tuberculosis, bacterial infections, or fungal infections. Baricitinib can suppress the immune system, which may increase the risk and severity of infections. Therefore, it should not be used during active infections.
1.3. Live Vaccinations:
Baricitinib should not be administered concurrently with live vaccines. Live vaccines contain weakened forms of the virus or bacteria that could potentially cause infection. Since Baricitinib can suppress the immune system, it may reduce the effectiveness of live vaccines and increase the risk of developing an infection.
1.4. Severe Hepatic Impairment:
Patients with severe hepatic impairment should avoid the use of Baricitinib. Baricitinib is primarily metabolized in the liver, and a compromised liver function can lead to increased exposure to the medication and potential adverse effects.
1.5. Pregnancy and Breastfeeding:
Baricitinib is not recommended during pregnancy. Adequate and well-controlled studies on the use of Baricitinib in pregnant women are lacking, and its potential risks to the fetus are uncertain. Additionally, it is unknown whether Baricitinib passes into breast milk, so caution should be exercised while using it during breastfeeding.
2. Precautions:
Apart from contraindications, there are certain precautions that should be considered when using Baricitinib. These precautions include:
2.1. Thrombosis:
Baricitinib has been associated with an increased risk of blood clots, including deep vein thrombosis (DVT) and pulmonary embolism (PE). Individuals with a history of these conditions or other risk factors for thrombosis should be closely monitored while using Baricitinib.
2.2. Gastrointestinal Perforations:
There have been rare reports of gastrointestinal perforations associated with Baricitinib. Patients with a history of gastrointestinal perforations or conditions that make them more susceptible to gastrointestinal perforations should use the medication with caution.
2.3. Laboratory Monitoring:
Regular monitoring of blood counts, liver function tests, and lipid levels is important during treatment with Baricitinib. This helps to ensure that any potential adverse effects are detected early and appropriate actions can be taken.
It is crucial to note that the information provided here is for informational purposes only. It is important to consult with a healthcare professional or pharmacist for specific advice regarding the use of Baricitinib and to discuss individual circumstances and possible contraindications or precautions.
In conclusion, Baricitinib (巴瑞替尼) is an effective medication used to treat rheumatoid arthritis, COVID-19, and alopecia areata. However, it is contraindicated in individuals with a known hypersensitivity, active infections, severe hepatic impairment, and during pregnancy and breastfeeding. Precautions should be taken in patients with a history of thrombosis, gastrointestinal perforations, and regular laboratory monitoring should be conducted. Always consult a healthcare professional before starting or changing any medication regimens, as they can provide personalized advice based on individual needs and circumstances.
此外，巴瑞替尼片还显示出在斑秃治疗中的潜力。斑秃是一种自身免疫性疾病，导致头发脱落并最终造成斑状脱发。研究发现，巴瑞替尼片可以调节免疫反应，减轻自身免疫攻击，并有助于头发再生。目前，对于巴瑞替尼片在斑秃治疗中的应用还处于研究阶段，但它给患者带来了新的希望。
